what role for pharmacokinetic and pharmacodynamic data?
P. Dellamonica* University Hospital, B.P. 3079, 06202 Nice Cedex 3, France Keywords: resistance, pharmacokinetics, pharmacodynamics Sir, Athough convergent findings from preclinical and clinical studies suggest that pharmacokinetics (PK) and pharmacodynamics (PD) might play an important part in the emergence of antibiotic-resistant bacterial strains, the potential value of PK/PD data in the assessment of new antibiotic drugs has been largely overlooked. Instead, PK/PD data are too often given a unique role the theoretical basis and justification for clinical trials and their importance in the evaluation of risk of in vivo selection of resistant strains remains an unresolved issue. Some observations made in vitro could indicate a possible line of research in the field. Carsenti-Etesse et al.1 reported that, after serial passages of clinical strains of Streptococcus pyogenes in subinhibitory concentrations of antibiotics, final erythromycin MICs reached intermediate and resistant levels.
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