What role does measuring medication compliance play in evaluating the efficacy of naltrexone?
Author(s): Baros AM, Latham PK, Moak DH, Voronin K, Anton RF Affiliation(s): Charleston Alcohol Research Center, MUSC, Charleston, South Carolina 29425, USA. baros@musc.edu Publication date & source: 2007-04, Alcohol Clin Exp Res., 31(4):596-603. Publication type: Randomized Controlled Trial; Research Support, N.I.H., Extramural BACKGROUND: Compliance with medication in pharmacotherapy trials of alcoholism has been shown to be equal to, or more, important than in other areas of medicine. Research has suggested that naltrexone’s effectiveness can be greatly influenced by the compliance of participants in clinical trials. Presently, we compare 2 compliance measurement methods [urine riboflavin and medication event monitoring system (MEMS)] used simultaneously to evaluate naltrexone’s efficacy and the impact of compliance on the size of observable treatment effects. METHODS: One hundred and thirty-seven of 160 randomized alcoholic patients completed 12-weeks (84 days) of naltrexone or pla
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