What role do B cells play in RA?
• B-cells are believed to play a role in the pathogenesis of rheumatoid arthritis (RA) and associated chronic synovitis. In this setting, B-cells may be acting at multiple sites in the autoimmune/inflammatory process, including through production of rheumatoid factor (RF) and other autoantibodies, antigen presentation, T-cell activation, and/or pro-inflammatory cytokine production. Reference: Rituxan [package insert]. South San Francisco, CA: Biogen Idec, Inc. and Genentech, Inc.; September 2008.
