What research has Zicam done to show that its Cold Remedy nasal products do not cause loss of smell?
The safety of Zicam Cold Remedy is substantiated with multiple studies: (1) An epidemiological study demonstrates that three of the most common conditions associated with anosmia are the common cold, sinusitis, and nasal injury. This population study in 3.7 million patients demonstrated statistically significant associations between anosmia and numerous medical conditions and multiple classes of drugs. These factors confound any attempt to attribute an association of anosmia with Zicam Cold Remedy zinc gluconate nasal gel. (2) Anatomic and behavioral data obtained in animal studies showed no detrimental effects on smell associated with single doses of Zicam intranasal zinc gluconate gel equivalent to between three and 6x the recommended dose for humans. Even at doses up to 15x the recommended dose, little or no effect to detect odors was uncovered. (3) Human in vivo and cadaver studies using our dosage form and nasal pump delivery device confirmed that Zicam intranasal zinc gluconate g
