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What prompted scientists to look for Transfer Factors in eggs and colostrum?

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What prompted scientists to look for Transfer Factors in eggs and colostrum?

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It was first noticed that when newborn cows didn’t or couldn’t nurse, they quickly died. Infection, and not starvation, was usually the cause. Researchers realized that the mother was passing immunity information to the calf after birth and that the only means could be transfer factors in her first milk, or colostrum. It was then realized that birds must also pass on immune information to their own young.

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