What programs are used for disease gene mapping?
APM: The Affected Pedigree Member Method distribution contains the new APM programs, a new file conversion utility, and a histogram/statistics generator. To build the entire distribution, you need C, Pascal, and FORTRAN compilers, and a make utility is also helpful. The programs which are built include: APM, a program to calculate the single locus statistic over one or several marker loci; SIM, a program to simulate pedigrees and, using output files of APM, test for asymptotic normality of the null distribution; APMMULT, a program to generate the multilocus statistic; SIMMULT, a program like SIM but which simulates recombination and uses the output of APMMULT; CHAPM, a program to convert LINKAGE files to APM files, or APM files of one format to APM files of another format; and HIST, a program to compute various statistical figures, plot a histogram, and compute empirical p-values. The APMember package by D. Weeks is available via anonymous FTP from watson.hgen.pitt.edu. Additionally, t
