What Processes Change during Progression?
I maintain my focus on rate processes that limit progression and influence age-specific incidence. However, we do not know exactly which processes play key roles in the dynamics of progression, and different cancers vary widely in their characteristics. So, I will provide a sample of potential issues to set the stage for formulating quantitative hypotheses in later chapters. I emphasize processes that influence cellular birth and death, processes that generate variation in cells and tissues, and processes that select the successful tumor variants (Hanahan and Weinberg 2000).
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