What precondition temperature should be used for gel pack refrigerants when designing and qualifying temperature controlled packages?
The answers to these questions provide very valuable information when designing temperature controlled packaging for pharmaceuticals or biologics for which very tight temperature ranges must be maintained. How frozen do the gel pack refrigerants have to be? When gel pack refrigerants are removed from the freezer they immediately begin to transition to their phase change temperature, roughly 0°C in the case of water-based gel packs, those most commonly used. If the gel pack refrigerants are removed from the freezer and immediately confined to a hermetically sealed insulated package, there is often a “thermal shock” that occurs – a brief but significant dip in internal air temperature within the package. This effect can be verified by placing a battery operated data logger monitoring device within the package or by probing the actual product within the package using thermocouple wire integrated with a temperature data logger. The lower the temperature to which the gel pack refrigerants a
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