What precautions are necessary when switching between nefazodone and an MAO inhibitor?
When switching from an MAO inhibitor to nefazodone, there should be a 14-day interval between the discontinuation of the MAOI and the initiation of nefazodone therapy. When switching from nefazodone to an MAOI, a 7-day interval is adequate, because of nefazodone’s short half-life. • What does nefazodone cost? Nefazodone is supplied in tablets ranging from 100 mg to 250 mg in strength. The 100 mg tablets cost pharmacies nearly as much as the 250 mg tablets. It is expected that all strengths of nefazodone will be sold for between $0.80 and $1.25 per tablet. • Might nefazodone be effective when a person has not responded to other antidepressants? Although there is no data on this, it is expected that some individuals who have failed to be helped by other antidepressants will be helped by nefazodone. • What are the advantages of nefazodone? The low incidence of sexual side-effects and disturbed sleep are possible advantages of nefazodone. • Has nefazodone been available in other countries?
