What personal, physical, and/or knowledge skills are required?
Each person is different, so there are no “required” personal skills. Physically, there is really not much of a limitation. Look at Stephen Hawking. So much is done with computers now, not only theory but even observation, that physical limitations are becoming less and less a problem. With respect to knowledge, Einsteins are one in a million. The rest of us just work very very hard.
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