What other drugs will affect isoniazid?
Before taking isoniazid, tell your doctor if you are taking any of the following drugs: • antacids. Aluminum salts will decrease the action of isoniazid. Do not take antacids that contain aluminum for 1 to 2 full hours before or after taking a dose of isoniazid. • ketoconazole (Nizoral) and itraconazole (Sporanox). Isoniazid may decrease the actions of these antifungal medicines. Therefore, a fungal infection may not be adequately treated. • rifampin (Rimactane, Rifadin) or rifabutin (Mycobutin). • disulfiram (Antabuse). Unusual behavior and coordination difficulties may occur if these medicines are taken together. Isoniazid may increase the effects of the following medicines: • warfarin (Coumadin); • carbamazepine (Tegretol); • cycloserine (Seromycin); • phenytoin (Dilantin), ethotoin (Peganone), and mephenytoin (Mesantoin); • meperidine (Demerol); • benzodiazepines such as alprazolam (Xanax), diazepam (Valium), lorazepam (Ativan), and temazepam (Restoril); • theophylline (Theo-Dur, T