What other drugs affect Vitamin C (Ascorbic Acid)?
Vitamin C may increase adverse effects associated with acetaminophen. Vitamin C may increase adverse effects associated with aluminum-containing antacids such as aluminum hydroxide (Maalox, Gaviscon). Vitamin C in high doses appears to interfere with the blood thinning effects of warfarin by lowering prothrombin time (PT), as noted in case reports in the 1970s. Complications have not been reported (such as increased blood clots). Vitamin C may increase blood levels and adverse effects of aspirin, whereas aspirin may decrease blood levels of vitamin C. The effects of vitamin C may be decreased by barbiturates including phenobarbital (Luminal, Donnatal), pentobarbital (Nembutal), or secobarbital (Seconal). Vitamin C supplementation may decrease levels of the drug fluphenazine in the body. Concomitant administration of high doses of vitamin C can reduce steady-state indinavir plasma concentrations. There is limited case report evidence that high dose vitamin C may reduce side effects of l
