What other cancer prevention trials are under way for colorectal cancer?
The NCI is sponsoring a number of prevention trials in which drugs or nutritional supplements are being tested to reduce the risk of developing polyps and/or colorectal cancer. Agents under study include sulindac and celecoxib (anti-inflammatory agents that inhibit an enzyme known as cyclo-oxygenase), and the nutrients folic acid and calcium. • What are the next steps? Polyp Prevention Trial researchers will continue to follow the participants in the trial to see if the dietary changes they made influence their likelihood of getting more polyps or colorectal cancer in the future. In addition, they are using the material from the polyps that were removed to find out whether the diet affected the molecular genetic characteristics of the polyps. The Wheat Bran Fiber Study researchers will also continue to follow the participants in their trial to see if they develop any additional polyps or colorectal cancer in the future. The researchers will follow study participants for lifestyle, gene
