What organic compound would be most soluble in a nonpolar substance?
Like dissolves like. Therefore, in a nonpolar solvent, the substance that would be the most soluble is a nonpolar compound. The types of organic compounds are carbohydrates (which are fairly polar, because they contain a lot of oxygen), nucleic acids (which are polar because of all the phosphate groups), proteins (which are often polar because of polar or ionic parts of amino acids), and lipids. Lipids are the least polar of all organic molecules, because they are mostly made of big chains of C and H– nonpolar covalent bonds. So lipids will be the most soluble in a nonpolar substance.
