What organelles do the thyroid follicular cells use to make thyroid hormone?
The thyroid follicular cells produce a 660,000 MW glycoprotein called thyroglobulin. It is produced by the organelle system that is designed to synthesize, package, and secrete glycoproteins. This would include the rough endoplasmic reticulum and the Golgi complex. The thyroid hormones are stored either as iodinated amino acids (tyrosines) in the thyroglobulin molecule. How do the cells produce and store the thyroglobulin?
