What means family a?
‘na’ means ‘not assigned’. Per definition, variable gene sequences that show a sequence identity of at least 80% belong to the same V gene family. The VBASE2 generation procedure aligns each V gene against a set of well established and manually edited family master (consensus) sequences. Some V genes which differ substantially from the master sequences can not be aligned properly. Thus, they cannot be assigned to a V gene family. The annotation ‘na’ is an evidence that this V gene is special. Many ‘na’ are pseudo genes or orphans.
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