What may happen in the event of an overdose of EXJADE?
Cases of overdose (2 to 3 times the prescribed dose for several weeks) have been reported. In one case, this resulted in hepatitis, which resolved without long-term consequences after a dose interruption. Single doses of up to 80 mg/kg/day in iron overloaded patients with β-thalassemia have been tolerated with nausea and diarrhea noted. In healthy volunteers, single doses of up to 40 mg/kg/day were tolerated. There is no specific antidote for EXJADE. In case of overdose, induce vomiting and gastric lavage.
