What life time should I expect from a Cyano Column?
While Cyano columns have suffered from a reputation of not lasting very long, with type B silica (high purity) and proper bonding technologies, a Cyano column that is conditioned and treated properly should last as long as any other column. To lengthen column life I recommend that you avoid using mobile phases with a pH higher than 7.0 with Cyano and Amino columns.