What Level of Serum Ferritin Is Too High for Further IV Iron Therapy?
IV iron and inflammation each beget a high serum ferritin. IV iron administration begets oxidant stress. IV iron in the presence of either inflammation or high ferritin begets oxidant stress disproportionately. Available information cannot convincingly absolve, individually or collectively, cumulative IV iron dose, high ferritin, or oxidant stress in the pathogenesis of cardiovascular disease in dialysis-dependent CKD patients. Thus, in determining a threshold ferritin above which no further IV iron should be given, concern for patient safety warrants use of a conservative and accepted standard: Do no harm. In short, evidence for efficacy must substantially outweigh evidence for risk. As the above discussion has made clear, the risks identified in patients with high ferritin values are indirect but troubling. Moreover, because the reported relationship between serum ferritin and oxidant stress is continuous (40,41), no distinct serum ferritin value emerges to serve as the cutoff for an
Related Questions
- I know eating foods high in iron or taking iron supplements will increase my iron level but will it also increase my ferritin level?
- Is serum neopterin level a marker of responsiveness to interferon beta-1a therapy in multiple sclerosis?
- What Level of Serum Ferritin Is Too High for Further IV Iron Therapy?
