What kinds of GO annotations are in the UniProtKB-GOA files?
The UniProtKB-GOA project at the EBI aims to provide high-quality Gene Ontology (GO) annotations to proteins in the UniProt Knowledgebase (UniProtKB) and International Protein Index (IPI) and is a central dataset for other major multi-species databases; such as Ensembl and NCBI. UniProtKB-GOA has been a member of the GO Consortium since 2001, and is responsible for the integration and release of GO annotations to the human, chicken and cow proteomes. In 2006 UniProtKB-GOA became a central participant in the new GOC Reference Genome Annotation project and is committed to the comprehensive annotation of a set of disease-related proteins in human. With this project the GOC intends to generate a reliable set of GO annotations for the twelve selected genomes that will also empower comparative methods used in first pass annotation of other proteomes. UniProtKB-GOA works closely with Swiss-Prot, InterPro and IntAct curators at the EBI, and HGNC and AgBase curators externally to create manual
