What kind of data does one get from an in vitro study?
A wealth of information can be obtained from in vitro percutaneous absorption studies. The primary parameters are Flux (rate and time course of penetration) and total amount absorbed. The flux data can also be converted to cumulative penetration results. When mass balance studies are conducted, residual surface dose and the distributed content within the stratum corneum, epidermis and dermis can also be determined. These parameters are reported as both mass/cm2 (e.g. µg/cm2) and as percent of applied dose. We have the experience to assist you in your study design to satisfy a wide variety of needs. For instance, a study can be designed to determine the time course of drug appearance in the epidermis and dermis, as well as the time course of penetration into the reservoir solution. ^ Top 8. How well does the in vitro data match in vivo? Percutaneous absorption represents the “A” in ADME (Absorption-Distribution-Metabolism-Excretion). Our early work in the 1970s and 1980s, which has sinc
