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What is urokinase plasminogen activator receptor (uPAR)?

April 26, 2017activator plasminogen receptor upar urokinase

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What is urokinase plasminogen activator receptor (uPAR)?

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uPAR is a cell-surface molecule that urokinase plasminogen activator (uPA) binds to. When bound to uPAR, uPA is activated converting plasminogen into plasmin. Plasmin digests fibrin, allowing room for endothelial tube formation. The urokinase plasminogen activator system plays a central role in malignant tumour progression. The researchers suggest combined green tea and G. lucidum extracts has the potential to suppress growth and invasiveness of metastatic breast cancers. [Int J Oncol. 2007 Apr;30(4):963-9.] More info about lingzhi here.