Important Notice: Our web hosting provider recently started charging us for additional visits, which was unexpected. In response, we're seeking donations. Depending on the situation, we may explore different monetization options for our Community and Expert Contributors. It's crucial to provide more returns for their expertise and offer more Expert Validated Answers or AI Validated Answers. Learn more about our hosting issue here.

What is Tryptophan Hydroxylase?

April 26, 2017hydroxylase Tryptophan

0

Posted

What is Tryptophan Hydroxylase?

1 Answer

0

Posted

I have recently read articles that describe MDMA as a Tryptophan Hydroxylase inhibitor. I understand MDMA’s effect on Serotonin levels in the brain, but what is Tryptophan Hydroxylase? Reply from Nick Cozzi Tryptophan hydroxylase is the rate-limiting enzyme in serotonin biosynthesis. It is present in serotonergic neurons and it catalyzes the addition of the 5-hydroxy group to tryptophan to give 5-hydroxytryptophan. This substance is then decarboxylated to give 5-hydroxytryptamine (serotonin). Nicholas V. Cozzi, Ph.D.