What is the Zinc Finger Nuclease (ZFN) technology?
Zinc finger nuclease technology is an exciting new tool for the study and manipulation of mammalian gene expression. This approach provides the researcher with the power to rapidly knock out or modify endogenous genes—or to knock in transgenes—in a highly targeted manner. At the core of this method is a versatile “zinc finger” DNA binding protein structure. Following on from pioneering work in several academic labs, over a decade of research at Sangamo BioSciences has led to a deep understanding of how this zinc finger domain recognizes and binds to DNA. Zinc finger nuclease technology is an exciting new tool for the study and manipulation of mammalian gene expression. This approach provides the researcher with the power to rapidly knock out or modify endogenous genes—or to knock in transgenes—in a highly targeted manner. At the core of this method is a versatile “zinc finger” DNA binding protein structure. Following on from pioneering work in several academic labs, over a decade of re
