What is the validation status of other assays of bioaccessibility?
A variety of in vitro lead bioaaccessibility assays have been reported; however, at this time only the assay described in the Lead TSD: Estimation of Relative Bioavailability of Lead in Soil and Soil-Like Materials Using In Vivo and In Vitro Methods (PDF)(386 pp, 4.9 MB) has been validated for applications in US EPA risk assessments. As described in the bioavailability guidance, other methods and associated validation data may be submitted to the Bioavailability Committee for consideration as valid test methods.
