What is the usual final dose of nefazodone?
While doses up to 600 mg per day are approved by the FDA, some severely depressed patients have been treated with higher doses. Most depressed people respond to doses under 600 mg per day. • How long does it take nefazodone to relieve depression? While most people taking nefazodone become aware of some lessening of depression within two to four weeks, there are some who experience relief within the first week and others who only experience relief after many weeks of therapy. • Are there withdrawal effects if nefazodone is suddenly discontinued? A withdrawal syndrome following the abrupt discontinuation of nefazodone has not been described. Because the half-lives of nefazodone and its active metabolites are 18 hours or less, it is prudent to taper nefazodone rather than abruptly discontinue it. • Is nefazodone toxic if an overdose is taken? Seven overdoses of nefazodone have been reported. The highest reported overdose was 11,200 mg. In some cases nefazodone was taken along with alcohol
