What Is the Treatment for Histoplasmosis in Pregnancy?
• Lipid formulation amphotericin B, 3.0 to 5.0 mg/kg/d, for 4 to 6 weeks is recommended (AIII). • The deoxycholate formulation of amphotericin B, 0.7 to 1.0 mg/kg/d is an alternative to a lipid formulation in patients who are at a low risk for nephrotoxicity (AIII). • If the newborn shows evidence for infection, treatment is recommended with amphotericin B deoxycholate 1.0 mg/kg/d for 4 weeks (AIII). What Treatment Is Recommended for Histoplasmosis in Children? Acute Pulmonary Histoplasmosis • Treatment indications and regimens are similar to adults, except that amphotericin B deoxycholate, 1.0 mg/kg/d is usually well tolerated, and the lipid preparations are not preferred (AIII). • Itraconazole dosage in children is 5.0 to 10.0 mg/kg/d in two divided doses, not to exceed 400 mg daily, generally using the solution formulation (AIII). Progressive Disseminated Histoplasmosis • Amphotericin B deoxycholate, 1.0 mg/kg/d for 4 to 6 weeks is recommended (AIII) • Amphotericin B deoxycholate, 1
