What is the significance of the fact that bretylium and guanethidine compete with TCAs for uptake process?
Does this interfere with the TCAs action? Answer: Neuronal uptake is an active process with limited capacity and can be saturated. The competition of guanethidine for neuronal uptake can reduce the effectiveness of agents that require it to gain access to the nerve terminal. Such as amphetamines for ADHD. TCAs or cocaine inhibit neuronal uptake and thus can decrease the action of guanethidine. Bretylium does not compete for neuronal uptake.
Related Questions
- What is the significance of the fact that bretylium and guanethidine compete with TCAs for uptake process?
- Why Robotic Welding Process is better Manual Welding, despite of the fact that labour is so cheap in India?
- Is there significance in the fact that the military intelligence file on Oswald disappeared?
