What is the role of mutations of RAS and PTPN11 in JMML?
A number of gene mutations are known to be involved in the development of JMML. RAS mutations are observed in approximately 30% of JMML cases while another 35% of patients harbor the PTPN11 mutation. These mutations are not inherited from parents and it remains largely unknown why some children acquire these genetic defects associated with JMML.
