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What is the risk of febrile seizures after the first dose of MMRV vaccine compared with the first dose of MMR and varicella vaccines administered at the same visit?

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What is the risk of febrile seizures after the first dose of MMRV vaccine compared with the first dose of MMR and varicella vaccines administered at the same visit?

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Two postlicensure studies evaluated the risk of febrile seizures after MMRV vaccine in children aged 12-23 months; one was sponsored by Merck and the other was sponsored by CDC and conducted through the Vaccine Safety Datalink (VSD), which is a collaboration between CDC and eight managed care organizations. Review of findings from both postlicensure studies supports the conclusion that children who receive the MMRV vaccine when they are 12-23 months old are about twice as likely to have a febrile seizure during the 5-12 days following vaccination when compared with those who receive the MMR and varicella vaccines at the same visit. However, the overall risk of febrile seizures is very low for both options (about 8 out of every 10,000 children vaccinated with MMRV vaccine when they are 12-23 months old, and about 4 out of every 10,000 children vaccinated with the MMR and varicella vaccines at the same visit when they are 12-23 months old). Studies of febrile seizures after vaccination w

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