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What is the risk of aplastic anaemia with chloramphenicol eye drops?

April 26, 2017anaemia aplastic chloramphenicol Drops eye risk

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What is the risk of aplastic anaemia with chloramphenicol eye drops?

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An association between the use of chloramphenicol eye drops and aplastic anaemia has been suggested. Case-control studies involving a population of 40 million people found no evidence of an increased risk.1 Another study,2 using a UK general practice database, identified 442 543 patients who received 674 148 prescriptions for chloramphenicol eye drops, 3 individuals experienced serious haematological toxicity. Recommendations to avoid use of chloramphenicol eye drops therefore appear to be not well founded and the BNF considers it the drug of choice for superficial eye infections.