What is the risk/benefit ratio of the research, compared with that of the available alternatives?
Note: The potential benefits of research must justify the risks to human subjects. Some risks may not be reasonable, no matter how important the potential benefits. The risk/benefit ratio of the research must be at least as favorable for the subjects as that presented by standard treatments for their condition. When comparing the risk/benefit ratio of research with that of available alternatives, the alternative of doing nothing, or watchful waiting, should be included in the analysis. The risks of the study are minimal. Blood collection and CT scans are routine procedures that present minimal risk to the subjects. The pathogenesis of HIV infection and its affect on the thymus through puberty and immediately post puberty are not well understood. This study may give valuable information regarding this, thus potentially leading to more effective treatments. Thus we feel that the benefits outweigh the risks.
