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What is the relationship between the activity expressed as ED50 and as units/mg?

April 26, 2017activity ed50 expressed MG relationship units

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What is the relationship between the activity expressed as ED50 and as units/mg?

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The median effective dose, ED50, is defined as the cytokine concentration at which the activity is 50% of the maximum response. This method of expressing potency should only be used for cytokines which have a dose-response curves of sigmoidal shape. The formula for converting the activity expressed as ED50 in ng/ml to the specific activity in units/mg is: 1 x 106 / (ED50 in ng/ml) = specific acitivity (units/mg).