What is the rationale for offering biochemistry tests to women less than 35 years old with twin pregnancies who do not have access to NT?
Women with twin pregnancies will be offered IPS if available. Women 35 years and older who do not have access to NT will also be offered the option of amniocentesis. Women younger than 35 years who do not have access to NT will be offered SIPS or Quad depending on their gestational age. While the best screen for Down syndrome and trisomy 18 for women with twin pregnancies is a screening test that includes NT, biochemistry alone continues to be a viable option for women at lower risk for these conditions. While the detection rates are lower for twin pregnancies than singletons, the detection rates achieved justify offering the test to women who wish screening for Down syndrome (Bush, 2005).
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