What is the rate of the gross mutation?
• In human, it is about 1%. The evidence is as follows: Human infertility is the failure of a couple to become pregnant after one year of regular, unprotected intercourse. About 10% of couples in reproductive age experience infertility in the world. There are multiple factors leading to infertility, one of them is chromosomal abnormality, which accounts for 15-25% infertility in human, the chromosomal abnormality is the gross mutation. There might be many more chromosomal abnormalities at submicroscopic levels, which are not easily studied with microscopic techniques. Based on data above, the rate of gross mutation should be around 1% (10% x 20% x 1/2). • Not all of the chromosomal abnormalities are caused by gross mutation at zygotes; they could be from gamete mutation. Gross mutation will cause miscarriages or spontaneous abortion, some of individuals with gross mutation do survive without any morphological changes; they are usually detected for their infertility.
Related Questions
- Similar gross mutation at fraternal zyotes is a only premise in the model. Why do you propose twins zygotes mutation in the model?
- How do we arrive at the mutation rate assumption (.002 or .004) for our genealogical DNA studies?
- Why is the gross rate quoted when other preference shares quote the net rate?
