What is the purpose of the bioavailability guidance?
The guidance addresses three issues: • a recommended process for deciding when to collect site-specific information on the oral bioavailability of metals in soils for use in human health risk assessments • a recommended process for documenting the data collection, analysis, and implementation of a validated method that would support site-specific estimates of oral bioavailability • general criteria that EPA will use to evaluate whether a specific bioavailability method has been validated for regulatory risk assessment purposes. This guidance is focused on media-specific relative bioavailability and does not address adjustments to default absolute bioavailability values. Also, this guidance applies only to human health risk assessment and is not necessarily applicable to ecological receptors. Finally, the guidance document provides information on methodologies for directly assessing bioavailability and does not pertain to indirect methods for predicting bioavailability (e.g., speciation
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