What is the Purpose of ISA (ionic strength adjuster)?
A. Unlike pH buffers, the ionic strength of ion solutions varies with the concentration of the ion to be measured. To maintain a constant ionic strength, a neutral salt is added, such that the total ionic strength is independent of the analyte concentration. In the example of chloride measurement, an ISA made from potassium nitrate is suitable; add this to the standards and samples so that the concentration “in the beaker” is around 0.1-0.4M. ISA’s can also be used to adjust the pH and to complex/precipitate undesired interferences; a good example is TISAB, which is used for Fluoride determination.
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