What is the proposed type and frequency of analysis?
Analysis and inference will be based on the intention-to-treat principle. Efforts will be made to ensure that follow up is complete for all subjects and that there are no missing values for any of the subjects for any variable. Blinding of independent coders will be retained until after the analysis is completed. Baseline characteristics of study subjects will be contrasted to ascertain that randomization has in fact produced comparable groups with respect to all variables that effect pain response and physiologic stability. The primary outcome of interest will be the pain response of the infant experiencing a tissue breaking procedure while co-bedding with his/her twin when compared to a twin infant experiencing a tissue breaking procedure receiving standard care (alone in incubator or crib). This analysis will compare the means in the two groups before and after treatment and contrast the mean difference between groups using 95 percent confidence intervals and a p value. The stratifi
