What is the prognosis and rate of progression for LGMD2B/Miyoshi?
The rate of progression of LGMD2B/Miyoshi is fairly slow compared to most other types of muscular dystrophy. Among the identified forms of LGMD, type 2B is one of the more slowly progressive forms. There have been some reports that Miyoshi has a slower progression than LGMD2B, while other reports indicate that the two are similar. This may reflect a difference in the initial muscles affected, since weakness in the calf muscles has less impact on a patient’s function than weakness in the hip muscles. However, the reported rates of progression and symptoms do vary significantly, which may be due to differences in the type of mutation or other genetic differences between populations studied. There have not been any reports of cardiomyopathy (dystrophy of the heart muscle) in either LGMD2B or MM. Nor have there been any reports that either condition significantly shortens life expectancy.
