What is the probability of generating replication-competent viruses?
Laboratory studies involving animals may present many different kinds of physical, environmental, and biological hazards. The specific hazards present in any particular animal facility are unique, varying according to the species involved and the nature of the research activity. The risk assessment for biological hazard should particularly focus on the animal facility’s potential for increased exposure, both to human pathogens and to zoonotic agents. The animals themselves can introduce new biological hazards to the facility. Latent infections are most common in field-captured animals or in animals coming from unscreened herds. For example, monkey b-virus presents a latent risk to individuals who handle macaques. The animal routes of transmission must also be considered in the risk assessment. Animals that shed virus through respiratory dissemination or dissemination in urine or feces are far more hazardous than those that do not. Animal handlers in research facilities working on infec
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