What is the Pharmacokinetic profile of Macrobid?
Absorption : Clarithromycin is absorbed rapidly from the GIT after oral administration, but its bioavailability is reduced to 50% – 55% because of rapid first-pass metabolism. Peak serum concentration reaches approximately 2 hrs after drug administration. Food delays drug absorption but does not alter its extent. T1/2 : The elimination half-lives of clarithromycin and 14-hydroxyclarithromycin (active metabolite) are approximately 3-7 hrs and 5-9 hrs respectively. Distribution : Clarithromycin is well distributed through the body and achieves higher concentrations in tissues than in the blood. Stability : Clarithromycin is 340 fold more stable in PH 1.39 than Erythromycin. High lighting features Excellent pharmacokinetic profile Like • Extensive distribution into lung tissue • Active both intracellularly & extracellularly • Greater concentrations in the tissues and fluid of respiratory tract than in plasma • Highly active against common and emerging respiratory pathogens • Rapid penetra
