What is the normal function of the TAZ gene?
The TAZ gene provides instructions for producing a group of proteins called tafazzins. Tafazzins seem to have two distinct functions in cells and tissues. First, tafazzins play a role in the maintenance of the inner membrane of energy-producing centers in cells (mitochondria). Specifically, these proteins are involved in maintaining levels of a specific type of fat (lipid) called cardiolipin, which is essential for energy production in the mitochondria. Tafazzins also promote the differentiation and maturation of cells that build bones (osteoblasts), while preventing cells that store fat (adipocytes) from maturing.
