What is the normal function of the BLM gene?
The BLM gene provides instructions for producing a protein that is a member of the RecQ DNA helicase family. DNA helicases are enzymes that unwind the two spiral strands of a DNA molecule. This activity is necessary before DNA can be copied (replicated) in preparation for cell division. During replication, each chromosome makes two identical DNA structures, called sister chromatids. The BLM helicase is believed to play a role in recognizing and preventing errors in DNA copying. This protein probably helps to maintain the structure and integrity of a person’s DNA.