What is the newly reported association of ileal-lymphoid nodular hyperplasia, autism, and MMR vaccine?
I have considered carefully the recent paper by Wakefield et al, published in the Lancet. This paper describes 12 children with ileal-lymphoid nodular hyperplasia. This condition has previously been described by Walker Smith, a co-author on the Lancet paper, as benign – “due to the frequency of its demonstration in asymptomatic children”. Other authors have found this condition to be common, occurring in 24% of barium follow-through examinations when investigating for suspected childhood chronic inflammatory bowel disease. Williams and Nicholls warn against misdiagnosis leading to inappropriate medication. Cumulative evidence suggests that this is indeed a benign condition, which disappears spontaneously, with no long-term sequelae. Since lymphoid nodular hyperplasia occurs commonly, it is not surprising that it occurred commonly in these autistic children, especially as they were referred to a paediatric gastroenterology unit . Four children, of the twelve reported, were said to have
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