What is the molecular pathology that underlies hippocampal memory decline?
Over a century ago Alois Alzheimer described the importance of neurofibrillary tangles in a woman who died with dementia at the age of 55 years; plaques having already been observed in brains by Blocq and Marinesco. In the 1960s, Martin Roth and colleagues at Newcastle started to look at the pathological basis of dementia in Alzheimer’s disease (AD) and identified neuritic plaques and tangles as the key determinants of clinical dementia.
