What is the mechanism of DNA Replication?
DNA molecules are synthesized by DNA polymerases from deoxyribonucleoside triphosphate (dNTP). The chemical reaction is similar to the synthesis of RNA strands. Both DNA and RNA polymerases can extend nucleic acid strands only in the 5′ to 3′ direction. However, the two strands in a DNA molecule are antiparallel. Therefore, only one strand (leading strand) can be synthesized continuously by the DNA polymerase. The other strand (lagging strand) is synthesized segment by segment.