What is the mechanism of action for phosphatidylserine?
A. The mechanism by which phosphatidylserine may work is through a very complicated interaction between immune system cells (perhaps macrophages) and adrenal cell receptors. What might be happening is that the phosphatidylserine supplement signals the immune cells in some way, which then interact with the adrenal cells to make them more/less sensitive to cortisol negative feedback, so the adrenals produce only a small amount of cortisol and then stop before an overproduction happens. This is very theoretical and very complex!