What is the mechanism behind latex-related occupational asthma?
Natural rubber latex causes asthma through an immune process leading to the production of IgE (the allergic antibody). The repeated deposition of latex allergen-bearing airborne particles onto mucosal surfaces of the lung causes sensitization. After sensitization, when reexposure occurs, the release of inflammatory mediators and production of allergic antibodies results in allergic asthma. Airborne latex depends on the use of powdered rubber gloves. Use of cornstarch-powdered latex gloves is associated with a high risk of occupational disease in glove-wearers. Airborne cornstarch particles carry latex allergens into the air. Reference: Fish JE. Occupational Asthma and rhinoconjunctivitis indced by natural rubber latex exposure. JACI 2002: 110: S75-81. Tomazic VJ, Shampaine EL, Lamanna et al. Cornstarch powder on latex products is an allergen carrier. JACI 1994: 93: 751-758. Who is at high risk for latex-related occupational asthma? Natural rubber latex (NRL) is used in many and varied
