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What is the link between endothelial dysfunction and heart disease?

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What is the link between endothelial dysfunction and heart disease?

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Endothelial dysfunction is associated with most cardiovascular diseases, especially coronary artery disease, which can lead to a heart attack. Endothelial dysfunction is considered to be an early marker of coronary artery disease as it usually precedes it decades before any signs or symptoms appear. In fact, many investigators in the cardiovascular field view endothelial dysfunction as the disease whose clinical manifestation is cardiovascular disease.

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