What is the lethal dose of Diphenhydramine Hcl?
The LD50 of Diphenhydramine in rats is 500mg/kg. For humans it is not known, so be careful! Lethal doses in humans are almost always far less than lethal doses in rats (allowing for body weight differences), so don’t try to take the rat LD50 and apply it to yourself. Also, note that the LD50 is the dose at which 50% of the subjects will die. A lower dose will still kill a smaller proportion of the subjects – i.e. it may be that the LD10 (i.e. 10% mortality) for rats is just 100 mg/kg.
The LD50 of Diphenhydramine in rats is 500 mg/kg. For humans it is not known, so be careful! Lethal doses in humans are almost always far less than lethal doses in rats (allowing for body weight differences), so don’t try to take the rat LD50 and apply it to yourself. Also, note that the LD50 is the dose at which 50% of the subjects will die. A lower dose will still kill a smaller proportion of the subjects – i.e. it may be that the LD10 (i.e. 10% mortality) for rats is just 100 mg/kg.
